Immunosuppressive Bibenzyl‐phenylpropane Hybrids from Dendrobium devonianum
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Published:2023-03
Issue:3
Volume:20
Page:
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ISSN:1612-1872
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Container-title:Chemistry & Biodiversity
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language:en
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Short-container-title:Chemistry & Biodiversity
Author:
Zhan Rui1ORCID,
Zhang Xin‐Yue1,
Li Zhi‐Yuan2,
Liu Bo1,
Chen Ye‐Gao1
Affiliation:
1. School of Chemistry and Chemical Engineering Yunnan Normal University Kunming 650050 P. R. China
2. Medical Research Center The Affiliated Hospital of Qingdao University Qingdao 266003 China
Abstract
AbstractTwo new bibenzyl‐phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1–9 were specifically immunosuppressive to T lymphocytes with IC50 values ranging from 0.41 to 9.4 μM, of which compounds 1 (IC50=1.62 μM) and 2 (IC50=0.41 μM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
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