Affiliation:
1. School of Chinese Materia Medica & School of Life Sciences Beijing University of Chinese Medicine Beijing 100029 P. R. China
2. Institute of Clinical Medical Sciences & Department of Pharmacy China-Japan Friendship Hospital Beijing 100029 P. R. China
Abstract
AbstractPhytochemical investigation of the roots of Euphorbia ebracteolata Hayata resulted in the isolation of three new rosane diterpenoids, euphebracteolatins C–E (1–3), along with fourteen known analogs (4–17). Their structures were determined on the basis of extensive spectroscopic analysis including HR‐ESI‐MS, 1D and 2D NMR. Euphebracteolatin C (1) contains a C‐1/C‐10 double bond and a keto group at C‐7, and euphebracteolatins D and E (2–3) possess an aromatic ring‐A in their skeleton. The plausible biogenetic pathways of all the isolates were also proposed. Furthermore, compounds 1 and 9 showed selective cytotoxicity against HepG2 cells with IC50 values of 14.29 and 12.33 μM, respectively, and 2–3 displayed moderate cytotoxicity against three human cancer lines, with IC50 values ranging from 23.69 to 39.25 μM.
Funder
National Natural Science Foundation of China
China-Japan Friendship Hospital
Chinese Academy of Medical Sciences
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
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