Affiliation:
1. Department of Pharmaceutical Engineering School of Chemistry and Chemical Engineering and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission North Minzu University Yinchuan 750021, P.R. China
2. State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100191 China
Abstract
AbstractFour previously undescribed diastereomeric lignan glycosides, namely cistadesertosides B−E (1–4) were isolated from the stems of cultural Cistanche deserticola in Tarim desert. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including IR, HR‐ESI‐MS, 1D and 2D NMR, circular dichroism (CD) data and chemical degradation. The in vitro anti‐inflammatory activity of the isolates was also investigated. It showed that compounds 3 and 4 exhibited potential effects with IC50 values of 21.17 μM and 26.97 μM, respectively (positive control quercetin, IC50, 10.01 μM).
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering