Affiliation:
1. Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education and Yunnan Province Yunnan Characteristic Plant Extraction Laboratory School of Chemical Science and Technology Yunnan University Kunming 650500 P. R. China
2. Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education School of Chemical Science and Technology Yunnan University Kunming 650091 P. R. China
3. Yunnan Institute of Microbiology Yunnan University Kunming 650091 P. R. China
Abstract
AbstractJiangchuanmycin (1), a new indole containing pyrrolizidine, and six known peptides (2–7) were obtained from the fermentation broth of a Streptomyces isolate collected from a sediment sample of Xingyun Lake, Jiangchuan, China. Their structures were elucidated on the detailed analysis of the HR‐ESI‐MS, 1D and 2D NMR, ECD, and X‐ray crystallographic data. Jiangchuanmycin (1) presented weak inhibitory effects on cell lines of H1299, MHCC97H, HCT116 with the IC50 values of 97.6 μM, 98.6 μM and 40.6 μM, respectively.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
2 articles.
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