Two New Alkaloids from Roots of <i>Zea mays</i> and Their Cytotoxic Activity against Hep3B and SW480 Cells-Reference-Cited by-同舟云学术

Two New Alkaloids from Roots of Zea mays and Their Cytotoxic Activity against Hep3B and SW480 Cells

Published:2023-11-16 Issue:12 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Zhang Yunqiang¹²^ORCID,Liu Jianyu³,Zhang Yiling¹²,Qiu Xue¹²,Wang Andong⁴,Xu Yongnan³⁴

Affiliation:

1. School of Traditional Chinese Medicine Shenyang Pharmaceutical University Shenyang 110016 China

2. Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education, Shenyang Pharmaceutical University Shenyang 110016 China

3. School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

4. School of Pharmacy Nantong University Nantong Jiangsu 226001 P. R. China

Abstract

AbstractTwo undescribed alkaloids, along with seven known compounds, were isolated from the roots of Zea mays (RM). Their chemical structures were elucidated based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR, and CD spectra. Two new alkaloids exhibited moderate inhibition of Hep3B (IC50 values of 11.7±2.4 and 14.2±3.6 μM) and SW480 cells (IC50 values of 33.4±8.2 and 47.3±5.8 μM) compared to that of the positive control compound, Oxaliplatin, IC50 value of 8.4±1.7 and 45.8±5.6 μM, respectively.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202301505

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