Affiliation:
1. Faculty of Science and Technology Shizuoka Institute of Science and Technology 2200-2 Toyosawa Fukuroi Shizuoka 437-8555 Japan
2. Faculty of Life Science and Biotechnology Fukuyama University 1 Gakuen-cho Fukuyama Hiroshima 729-0292 Japan
3. Department of Biosciences and Biotechnology, Faculty of Agriculture University of the Ryukyus 1 Senbaru Nishihara Okinawa 903-0213 Japan
4. Shizuoka Prefectural Research Institute of Fishery and Ocean 136-24 Iwashigashima Yaizu Shizuoka 425-0032 Japan
5. Artificial Intelligence Research Center, SANKEN Osaka University Mihogaoka Ibaraki Osaka 567-0047 Japan
6. Coastal Branch of Natural History Museum and Institute, Chiba 123 Yoshio Katsuura Chiba 299-5242 Japan
Abstract
AbstractThe marine red algal genus Laurencia has abundant halogenated secondary metabolites, which exhibit novel structural types and possess various unique biological potentials, including antifouling activity. In this study, we report the isolation, structure elucidation, and antifouling activities of two novel brominated diterpenoids, aplysin‐20 aldehyde (1), 13‐dehydroxyisoaplysin‐20 (2), and its congeners. We screened marine red alga Laurencia venusta Yamada for their antifouling activity against the mussel Mytilus galloprovincialis. Ethyl acetate extracts of L. venusta from Hiroshima and Chiba, Japan, were isolated and purified, and the compound structures were identified using 1D and 2D NMR, HR‐APCI‐MS, IR, and chemical synthesis. Seven secondary metabolites were identified, and their antifouling activities were evaluated. Compounds 1, 2, and aplysin‐20 (3) exhibited strong activities against M. galloprovincialis. Therefore, these compounds can be explored as natural antifouling drugs.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
1 articles.
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