Five New C21‐Steroidal Sapogenins from the Acid Hydrolysate of Cynanchum otophyllum Roots

Author:

Li Xiao‐San12ORCID,Liang Xiao‐Yan12,Liu Ming‐Shang1,Wang Qi‐Lin1,Zhan He‐Hui1,Xu Zhi‐Peng3,Liu Li1,Huang Yong‐Mei12,Yang Mao‐Xun12,Luo Hui12

Affiliation:

1. Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs and School of Pharmacy Guangdong Medical University Dongguan 523808 P. R. China

2. Marine Biomedical Research Institute the Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim Guangdong Medical University Zhanjiang 524023 P. R. China

3. Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou 510632 P.R. China

Abstract

AbstractFive new C21‐steroidal sapogenins (15) named cynotogenins J−N, were isolated from the acid hydrolysate of Cynanchum otophyllum roots. Their structures were established by extensive spectroscopic analysis (UV, IR, HR‐ESI‐MS, and NMR). Most notably, compounds 13 harboring a rare 5β,6β‐epoxy group in the C21‐steroidal skeleton of Cynanchum plants. All compounds were evaluated for their cytotoxicities against multiple cancer cell lines, in which compounds 5 showed weak cytotoxicity against HepG2 cancer cells with IC50 values of 44.90 μM.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Reference22 articles.

1. P. T. Li G. G. Michael W. D. Stevens Z. Y. Wu H. R. Peter ‘Flora of China’ Beijing: Science Press1995 205–223.

2. New pregnane glycosides from the roots of Cynanchum otophyllum

3. ‘Recent advances in phytochemistry and pharmacology of C21 steroid constituents from Cynanchum plants’;Gu X. J.;Chin. J. Nat. Med.,2016

4. C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum

5. Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3