Affiliation:
1. Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs and School of Pharmacy Guangdong Medical University Dongguan 523808 P. R. China
2. Marine Biomedical Research Institute the Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim Guangdong Medical University Zhanjiang 524023 P. R. China
3. Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou 510632 P.R. China
Abstract
AbstractFive new C21‐steroidal sapogenins (1–5) named cynotogenins J−N, were isolated from the acid hydrolysate of Cynanchum otophyllum roots. Their structures were established by extensive spectroscopic analysis (UV, IR, HR‐ESI‐MS, and NMR). Most notably, compounds 1–3 harboring a rare 5β,6β‐epoxy group in the C21‐steroidal skeleton of Cynanchum plants. All compounds were evaluated for their cytotoxicities against multiple cancer cell lines, in which compounds 5 showed weak cytotoxicity against HepG2 cancer cells with IC50 values of 44.90 μM.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
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