Affiliation:
1. Department of Chemistry College of Chemistry and Materials Science Jinan University Guangzhou 510632 China
2. Research Center for Marine Drugs State Key Laboratory of Microbial Metabolism Department of Pharmacy, Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China
Abstract
AbstractTwo new cytochalasans, marcytoglobosins A (1) and B (2) were isolated from the marine sponge associated fungus Chaetomium globosum 162105, along with six known compounds (3–8). The complete structures of two new compounds were determined based on 1D/2D NMR and HR‐MS spectroscopic analyses coupled with ECD calculations. All eight isolates were evaluated for their antibacterial activity. Among them, compounds 3–8 displayed antibacterial effects against Staphylococcus epidermidis, Bacillus thuringiensis, Pseudomonas syringae pv. Actinidiae, Vibrio alginolyticus, and Edwardsiella piscicida with minimum inhibitory concentration (MIC) values ranging from 10 to 25 μg/mL.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China