Affiliation:
1. School of Pharmacy Guangdong Pharmaceutical University 280 Huandong Road University City, Panyu District Guangzhou 510006 China
2. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology South China State Key Laboratory of Applied Microbiology 100 Central Xianlie Road, Yuexiu District Guangzhou 510070 China
Abstract
AbstractFour new phomalones A−D (1–4), together with five known analogues (5–9) were isolated from the deep‐sea‐derived fungus Trichobotrys effuse FS522. Their structures of the new compounds established by analysis of their NMR and HR‐ESI‐MS spectroscopic data, and the absolute configurations of 2 was determined by electronic circular dichroism (ECD) calculations. compounds 4, 6 and 8 substantially inhibited the production of nitric oxide (NO) with IC50 values of 4.64, 13.90, and 34.07 μM.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering