Affiliation:
1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China
2. State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 China
Abstract
AbstractTwo new dihydroisocoumarins, exserolides L and M (1 and 2), along with six known compounds (3–8) were isolated from the extract of the marine‐sponge‐derived fungus Setosphaeria sp. SCSIO41009. Their structures were established by spectroscopic analyses. The absolute configurations of two new compounds were determined by modified Mosher's method and ECD data. Compounds 1 and 4 showed significant antiviral activities against A/Puerto Rico/8/34 H274Y (H1 N1) with IC50 values of 4.07±0.76 μM and 20.06±4.85 μM, respectively.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province
National Natural Science Foundation of China
Cited by
2 articles.
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