Affiliation:
1. Department of Pharmacy Faculty of Pharmacy Al-Zaytoonah University of Jordan Amman 11733 Jordan
Abstract
AbstractCigarette smoking exacerbates respiratory diseases, while plant‐derived polyphenols offer antioxidant and anti‐inflammatory benefits. This study exploresd the effects of Rhoifolin (ROF), a polyphenol from Jordanian Teucrium polium, on lung health in rats exposed to tobacco smoke. Male rats were divided into two groups: one exposed to cigarette smoke (CS), and the other to ROF treatment alongside smoke exposure (CS/ROF). ROF was administered orally for 21 days before smoke exposure. Results showed smoke‐induced lung inflammation and oxidative stress, mitigated by ROF treatment. Histological examination revealed smoke‐related morphological changes in lung tissue. ROF treatment reduced oxidative stress and inflammation, as evidenced by decreased proinflammatory cytokines. In silico docking demonstrated ROF's potential as an inhibitor of proinflammatory cytokines. This study demonstrates the therapeutic potential of ROF and similar polyphenols in mitigating the harmful effects of cigarette smoke on lung health.
Funder
Al-Zaytoonah University of Jordan
Reference39 articles.
1. Estimation of the global number of e-cigarette users in 2020
2. WHO https://www.who.int/news-room/fact-sheets/detail/tobacco 2022.
3. Cannabis smoking and respiratory health: Consideration of the literature
4. H. R. Witschi et al. Toxic Responses of the Respiratory System 5th ed McGraw-Hill Health Professions Division New York NY2008 609–630.
5. Effects of cigarette smoke on the immune system