The Discovery and Anti‐Colorectal Cancer Activities of Cembranolides from the South China Sea Soft Coral Sinularia pendunculata

Abstract

AbstractA new cembranolide, namely, sinupendunculide A (1), along with eight known related compounds (2–9), was isolated from the South China Sea Soft coral Sinularia pendunculata. The structure of sinupendunculide A (1) was established by extensive spectroscopic analysis and X‐ray diffraction experiments. In a bioassay, anti‐colorectal cancer (CRC) activity was performed, and the results showed that several compounds exhibited cytotoxicity against RKO cells, and a preliminary structure‐activity relationship was analysed. Meanwhile, the most effective compound 7 was proven to increase reactive oxygen species levels, which promoted cell apoptosis and inhibited cell proliferation.