Taxodin A, a Cytotoxic C<sub>30</sub> Terpenoid from <i>Taxodium mucronatum</i> with a Unique Skeleton-Reference-Cited by-同舟云学术

Taxodin A, a Cytotoxic C₃₀ Terpenoid from Taxodium mucronatum with a Unique Skeleton

Published:2024-04-22 Issue:5 Volume:21 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Li Yao¹²,Zhou Zhi‐Ping¹²,Chen Li‐Ting¹²,Zhao Qin‐Shi¹^ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences 650201 Kunming People's Republic of China

2. University of Chinese Academy of Sciences 100049 Beijing People's Republic of China

Abstract

AbstractTaxodin A (1), a unique C30 terpenoid featuring an unprecedented skeleton composed of an abietane‐type diterpene and a menthane‐type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X‐ray single‐crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC‐7721, MDA‐MB‐231, and SW480 cell lines with IC50 values of 15.35±0.73, 8.49±0.35, 17.53±0.79, 18.93±0.60 μM, respectively.

Funder

Yunnan Provincial Science and Technology Department

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202400648

Reference21 articles.

1. Ethnobotany, Phytochemistry, and Biological Activities of Taxodium Rich.

2. Antifungal Abietane-Type Diterpenes from the Cones of Taxodium distichum Rich

3. Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE

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