Affiliation:
1. State Key Laboratory of Phytochemistry Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 People's Republic of China
2. University of Chinese Academy of Sciences Beijing 100049 People's Republic of China
Abstract
AbstractOne new fawcettimine‐type Lycopodium alkaloid, hupertimine F (1), together with five known (2–6) Lycopodium alkaloids were isolated from Huperzia goebelii. The structure of 1 was elucidated by 1D and 2D NMR spectra, HRESIMS, and X‐ray diffraction. Structurally, 1 represents the fourth example of Lycopodium alkaloids characterized by a 5/5/5/5/6 pentacyclic ring system with a 1‐aza‐7‐oxabicyclo[2.2.1]heptane moiety. These known compounds 2, 3, 5, and 6 were isolated from H. goebelii for the first time. Compounds 1–6 were evaluated for acetylcholinesterase, butyrylcholinesterase and monoamine oxidase B inhibitory activities in vitro.
Funder
National Natural Science Foundation of China
Yunnan Provincial Science and Technology Department