Neuromodulation of Acid‐Sensitive Ion Channels (ASICs) and Anti‐Inflammatory Potential by Lichenxanthone in Adult Zebrafish (<i>Danio rerio</i>): Experimental and Docking Studies-Reference-Cited by-同舟云学术

Neuromodulation of Acid‐Sensitive Ion Channels (ASICs) and Anti‐Inflammatory Potential by Lichenxanthone in Adult Zebrafish (Danio rerio): Experimental and Docking Studies

Published:2024-02-23 Issue:4 Volume:21 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Ribeiro Liberato Hortência¹,Bezerra Maciel Jéssica¹,Wlisses Da Silva Antônio²,Eduarda Uchoa Bezerra Maria¹,San De Oliveira Brito Luana³,Silva Jacilene¹,Kuerislene Amâncio Ferreira Maria¹,Machado Marinho Marcia¹,Marinho Gabrielle S¹,Deusdênia Loiola Pessoa Otília³,Guedes Maria Izabel F⁴,Goberlânio De Barros Silva Paulo⁵,Ferreira de Castro Gomes Andreia⁶,Silva Alencar De Menezes Jane Eire¹,Silva Dos Santos Hélcio¹⁷^ORCID

Affiliation:

1. Programa de Pós-graduação em Ciências Naturais Universidade Estadual do Ceará Fortaleza Ceará Brazil

2. Rede Nordeste de Biotecnologia Universidade Estadual do Ceará Fortaleza Ceará Brazil

3. Departamento de Química Orgânica e Inorgânica Universidade Federal do Ceará Campus do Pici s/n Fortaleza Ceará Brazil

4. Centro de Ciências da Saúde Universidade Estadual do Ceará Fortaleza Ceará Brazil

5. Programa de Pós-graduação em Odontologia, Centro Universitário Unichristus Fortaleza Ceará Brazil

6. Centro de Biologia Molecular e Ambiental Universidade do Minho Escola de Ciências, Departamento de Biologia Braga Portugal.

7. Universidade Estadual do Vale do Acaraú, Centro de Ciências Exatas e Tecnologia Sobral Ceará, Brasil.

Abstract

AbstractThe xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid‐sensitive ion channels (ASICs). In the analysis of anti‐inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by k‐carrageenan 3.5 %, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control). No leukocyte infiltrates were observed in lichenxanthone, suggesting that the compound acts in the acute inflammatory response. The results of the molecular docking study revealed that lichenxanthone exhibited better affinity energy when compared to the ibuprofen control against the two targets evaluated.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202400063

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