Affiliation:
1. School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products/College of Modern Biomedical Industry NHC Key Laboratory of Drug Addiction Medicine Kunming Medical University Kunming 650500 People's Republic of China
2. The First People's Hospital of Liangshan Prefecture Sichuan 615000 People's Republic of China
Abstract
AbstractGinseng saponins (ginsenosides), bioactive compounds derived from ginseng, are widely used natural products with potent therapeutic properties in the management of various ailments, particularly tumors, cardiovascular and cerebrovascular diseases, and immune system disorders. Autophagy, a highly regulated and multistep process involving the breakdown of impaired organelles and macromolecules by autophagolysosomes and autophagy‐related genes (ATGs), has gained increasing attention as a potential target for ginsenoside‐mediated disease treatment. This review aims to provide a comprehensive overview of recent research advances in the understanding of autophagy‐related signaling pathways and the role of ginsenoside‐mediated autophagy regulation. By delving into the intricate autophagy signaling pathways underpinning the pharmacological properties of ginsenosides, we highlight their therapeutic potential in addressing various conditions. Our findings serve as a comprehensive reference for further investigation into the medicinal properties of ginseng or ginseng‐related products.
Funder
National Natural Science Foundation of China