Two New Eudesmane‐Type Sesquiterpene from <i>Clonostachys</i> sp. Y6‐1and Their Cytotoxic Activity-Reference-Cited by-同舟云学术

Two New Eudesmane‐Type Sesquiterpene from Clonostachys sp. Y6‐1and Their Cytotoxic Activity

Published:2023-08-22 Issue:9 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Wang Mengru¹,Yang Run²,Chen Yuansi¹,Ni Dongxuan¹,Bi Dewen¹,Li Qi²,Huang Jiabi¹,Wang Hairong¹,Wang Weiguang²,Li Hongliang¹,Xiao Weilie¹^ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy, School of Medicine, and School of Chemical Science and Technology Yunnan University Kunming 650500 P. R. China

2. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission Yunnan Minzu University Kunming 650031 P. R. China

Abstract

AbstractTwo undescribed eudesmane‐type sesquiterpenoids together with four known compounds were isolated from Clonostachys sp. Y6‐1 associated. Their chemical structures were unambiguously determined by NMR, mass spectrometry, and 13C‐NMR calculation as well as DP4+ probability analyses. The absolute configurations of compounds 1 and 2 were determined by ECD calculation and X‐ray single‐crystal diffraction methods. Furthermore, all isolates were evaluated for in vitro cytotoxic activities against MCF‐7, HCT‐116, MDA‐MB‐231, and SW620 cancer cells. Among them, bioactivity evaluation of compound 5 revealed that weak activity (IC50=66.55±0.82 μM) against SW620.

Funder

Program for Changjiang Scholars and Innovative Research Team in University

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202300953

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