Affiliation:
1. Institute of Chemistry of Additives Ministry of Science and Education of the Republic of Azerbaijan 1029 Baku Azerbaijan
2. Baku State University Z. Khalilov Str. 23 AZ-1148 Baku Azerbaijan
3. Ataturk University Faculty of Science Department of Chemistry 25240 Erzurum Türkiye
4. Ardahan University Nihat Delibalta Göle Vocational High School Department of Pharmacy Services 75700 Ardahan Türkiye
5. Van Yüzüncü Yıl University Van Vocational School of Health Services 65080 Van Türkiye
Abstract
Abstract1,3‐Diheterocycloalkanes derivatives are important starting materials in fine organic synthesis. These compounds can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. The paper is focused on synthesis and study of alkoxymethyl derivatives of diheterocycloalkanes (M1–M15) and inhibition effect on carbonic anhydrase and acetylcholinesterase. The structures of compounds were confirmed by 1H and 13C NMR spectroscopy. Also, in this study alkoxymethyl derivatives of diheterocycloalkanes were assessed for their influence on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoenzymes (hCA I and hCA II). The results demonstrated that all these compounds exhibited potent inhibitory effects on all the target enzymes, surpassing the standard inhibitors, as evidenced by their IC50 and Ki values. The Ki values for the compounds concerning AChE, hCA I, and hCA II enzymes were in the ranges of 1.02±0.17–8.38±1.02, 15.30±3.15–58.14±5.17 and 24.05±3.70–312.94±27.24 nM, respectively.