Affiliation:
1. College of Pharmacy Guizhou University South Section of Huaxi Road 2078 Guiyang 550025 P.R. China
2. State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University 3491 Baijin Road Guiyang 550014 P. R. China
3. Kunming Institute of Botany Chinese Academy of Sciences (CAS) 132 Lanhei Road Kunming 650201 P. R. China
Abstract
AbstractThree new compounds, including two new sesquiterpenes (1–2), named Annuumine E−F, and one new natural product, 3‐hydroxy‐2,6‐dimethylbenzenemethanol (3), together with seventeen known compounds (4–20) were isolated from the ethanol extract of the roots of Capsicum annuum L. Among them, five compounds (4, 5, 9, 10 and 20) were isolated from this plant for the first time. The structures of new compounds (1–3) were determined via detailed analysis of the IR, HR‐ESI‐MS and 1D and 2D NMR spectra. The anti‐inflammatory activities of the isolated compounds were evaluated by their ability to reduce NO release by LPS‐induced RAW 264.7 cells. Notably, compound 11 exhibited moderate anti‐inflammatory activity (IC50=21.11 μM). Moreover, the antibacterial activities of the isolated compounds were also evaluated.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering