Affiliation:
1. Institute of Marine Drugs Guangxi University of Chinese Medicine Wuhe Road 13 530200 Nanning China
2. Guangxi Key Laboratory of Marine Drugs Guangxi University of Chinese Medicine Wuhe Road 13 530200 Nanning China
3. The Marine Biomedical Research Institute Guangdong Medical University Wenming East-Road 2 524023 Zhanjiang Guangdong China
4. The Marine Biomedical Research Institute of Guangdong Zhanjiang Wenming East-Road 2 524023 Zhanjiang Guangdong China
Abstract
AbstractA new alkaloids, aplysingoniopora A (1), and new configuration pregnane type steroid compound, 9,17‐α‐pregn‐1,4,20‐en‐3‐one (2), and two known pregnane type steroid compounds (3 and 4) were isolated from hydranth of Goniopora columna corals. The compounds structures and absolute configurations were determined by extensive spectroscopic analysis, MS data, single‐crystal X‐ray diffraction analysis and quantum chemical calculation. The anticancer effect of the compounds were explored in human non‐small‐cell lung cancer (NSCLC) A549 cell lines. As the results, the compound 3 and 4 induces toxicity and has proliferation inhibitory effects on A549 cells (IC50=58.99 μM and 58.77 μM, respectively) in vitro.
Funder
Guangdong Medical Research Foundation