Affiliation:
1. Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam
2. Graduate University of Science and Technology VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam
3. Faculty of Basic Sciences University of Transport and Communications Hanoi 11512 Vietnam
Abstract
AbstractFour previously undescribed compounds named phyllancosides A and B (1 and 2), and phyllancochines A and B (3 and 4) together with ten known compounds (5‐14) were isolated from the aerial parts of Phyllanthus cochinchinensis Spreng. Their chemical structures were elucidated on the basis of comprehensive analysis of IR, HR‐ESI‐MS, 1D and 2D NMR spectra. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD) spectra. Compounds 3, 4, and 10 showed antimicrobial activity against E. faecalis, S. aureus, and B. cereus with the MIC values in range of 32–256 μg/mL. Compound 11 inhibited E. faecalis and B. cereus, and 7 inhibited S. aureus with the MIC values in range of 64–128 μg/mL. In addition, compounds 1, 3, 4, 8, and 9 showed significantly NO production inhibitory activity in LPS activated RAW 264.7 cells with IC50 values ranging from 36.57 to 56.34 μM.
Funder
Vietnam Academy of Science and Technology