Affiliation:
1. College of Chemistry and Life Science Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules Chengdu Normal University Chengdu 611130 P. R. China
2. Southwest Minzu University Chengdu 610041 P. R. China
Abstract
Abstract‘On Water’‐promoted the three‐component tandem Michael addition/D−A cycloaddition reaction in 80 °C at 3 h has been developed without employing any catalyst and organic solvent. The process allows facile access to polycyclic N‐heterocycles derivatives contain indole and maleimide from easily accessible starting materials in moderate to high yields (up to 91 %). Compared with conventional reaction conditions, this reaction not only improves the reaction efficiency and rate but also minimizes the side reaction.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering