Exploring the Therapeutic Potential of Lawsone and Nanoparticles in Cancer and Infectious Disease Management

Author:

Kamil Zaidan Haider1,Jasim Al‐Khafaji Hanadi Had2,Al‐dolaimy F.3,Abed Hussein Shaymaa4,Otbah Farqad Rand5,Thabit Daha6,Talib Kareem Ashwaq7,Ramadan Montather F.8,Hamood Sarah A.9,Alawadi Ahmed Hussien101112,Alsaalamy Ali13

Affiliation:

1. Nursing College Al-Mustaqbal University Hillah, Babylon Iraq

2. College of Chemistry The University of Jordan Amman Jordan

3. Al-Zahraa University for Women Karbala Iraq

4. Department of Medical Engineering Al-Manara College for Medical Sciences Maysan Iraq

5. Department of Dentistry Al-Noor University College Bartella Iraq

6. Medical Technical College Al-Farahidi University Baghdad Iraq

7. College of Pharmacy National University of Science and Technology Dhi Qar Iraq

8. College of Dentistry Al-Ayen University Thi-Qar Iraq

9. Department of Medical Engineering Al-Esraa University College Baghdad Iraq

10. College of Technical Engineering The Islamic University Najaf Iraq

11. College of Technical Engineering The Islamic University of Al Diwaniyah Qadisiyyah Iraq

12. College of Technical Engineering The Islamic University of Babylon Babylon Iraq

13. College of Technical Engineering Imam Ja'afar Al-Sadiq University Al-Muthanna Iraq

Abstract

AbstractLawsone, a naturally occurring compound found in henna, has been used in traditional medicine for centuries due to its diverse biological activities. In recent years, its nanoparticle‐based structure has gained attention in cancer and infectious disease research. This review explores the therapeutic potential of lawsone and its nanoparticles in the context of cancer and infectious diseases. Lawsone exhibits promising anticancer properties by inducing apoptosis and inhibiting cell proliferation, while its nanoparticle formulations enhance targeted delivery and efficacy. Moreover, lawsone demonstrates significant antimicrobial effects against various pathogens. The unique physicochemical properties of lawsone nanoparticles enable efficient cellular uptake and targeted delivery. Potential applications in combination therapy and personalized medicine open new avenues for cancer and infectious disease treatment. While clinical trials are needed to validate their safety and efficacy, lawsone‐based nanoparticles offer hope in addressing unmet medical needs and revolutionizing therapeutic approaches.

Publisher

Wiley

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