Affiliation:
1. School of Life Science and Engineering Southwest Jiaotong University Chengdu Sichuan P. R. China
2. Yibin Institute of Southwest Jiaotong University Yibin Sichuan 644000 P. R. China
3. The Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu Chengdu Sichuan 610031 P. R. China
Abstract
AbstractFour new aconitine‐type C19‐diterpenoid alkaloids, were isolated from the roots of Aconitum nagarum Stapf which were named as nagarutines A–D (1–4), together with eleven known compounds (5–15). The structures of the compounds were identified by IR, HR‐ESI‐MS, 1D and 2D NMR spectra. All compounds were tested for the inhibitory effect on LPS induced NO production in RAW 264.7 macrophages, compound 7 showed moderate anti‐inflammatory activity effect and Inhibition rate is about 44.50%.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
1 articles.
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