Study on Chemical Components from Derris taiwaniana and Their Lung Epithelial Cell Protect Effects

Abstract

AbstractThe ethanol extract of roots of Derris taiwaniana gave two undescribed compounds, 3,3′‐dimethoxy‐5′‐hydroxystilbene‐4‐O‐β‐apiofuranosyl‐(1→6)‐β‐D‐glucopyranoside (1) and 4′,5‐dihydroxy‐3′‐methoxyisoflavone‐7‐O‐β‐apiofuranosyl‐(1→6)‐β‐D‐glucopyranoside (2), along with thirty known components. Among them, compounds 14, 16–17, 23, 26–32 were isolated from this genus for the first time. Their structures were established based on physico‐chemical properties and spectroscopic data, the lung epithelial cell protective effects were evaluated using NNK‐induced MLE‐12 cells. Among them, 2α,3α‐epoxy‐5,7,3′,4′‐tetrahydroxyflavan‐(4β‐8‐catechin) (30) showed the best significant protective effect, speculated to be the key component of D. taiwaniana that plays a protective role in lung epithelial cells.