Affiliation:
1. Department of Chemistry Mindanao State University-Iligan Institute of Technology Iligan City 9200 Philippines
2. Department of Chemistry Central Mindanao University Maramag Bukidnon 8714 Philippines
3. Graduate School of Integrated Sciences for Life Hiroshima University 1-7-1 Kagamiyama Higashi Hiroshima 739-8521 Japan
Abstract
AbstractFour new psammaplysin derivatives (1–4) with fatty acyl substituents, designated irciniaplysins A−D, and three known psammaplysins (5–7) were isolated from a marine sponge Ircinia sp. Their structures were elucidated using extensive spectroscopic analyses. The positions of the double bonds and the branch points of the fatty acyl side chains were determined by GC‐MS analysis of their fatty acid methyl ester (FAME) derivatives. Irciniaplysins A (1) and B (2) contained an unusual long‐chain fatty acyl substituent with a 5,9‐diene unit. The isolated compounds were evaluated for their cytotoxic activity against the human colorectal carcinoma (HCT 116) cells, however, none of these compounds showed significant activity.