Biomimetic Chemical Reactions with Natural Products Using Metalloporphyrins and Salen Complexes as Catalysts: A Brief Review

Author:

Sousa Rita C. N.1,Confessor Vitor P. P.2ORCID,Da Silva Antonio K. B.2ORCID,Almeida Addison R.12ORCID,Pinheiro Francisco A. S. D.2ORCID,Ferreira Leandro S.12ORCID

Affiliation:

1. Postgraduate Program in Chemistry Chemistry Institute Federal University of Rio Grande do Norte 59078-900 Natal-RN Brazil

2. Pharmacy Department Federal University of Rio Grande do Norte 59012-570 Natal-RN Brazil

Abstract

AbstractThe cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various secondary metabolites. Chemical catalysts are utilized to replicate the activities of enzymes. Metalloporphyrins and Salen complexes can contribute to the products’ characterization and elucidate biotransformation processes, which are investigated during pre‐clinical trials. These catalysts also help discover biologically active compounds and get better yields of products of industrial interest. This review aims to investigate which natural product classes are being investigated by biomimetic chemical models and the functionalities applied in the use of these catalysts. A limited number of studies were observed, with terpenes and alkaloids being the most investigated natural product classes. The research also revealed that Metalloporphyrins are still the most popular in the studies, and the identity and yield of the products obtained depend on the reaction system conditions.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Universidade Federal do Rio Grande do Norte

Publisher

Wiley

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