Xylarkarynone A and B: Two Bioactive Eremophilane Sesquiterpenes from <i>Xylaria</i> sp. HHY‐2-Reference-Cited by-同舟云学术

Xylarkarynone A and B: Two Bioactive Eremophilane Sesquiterpenes from Xylaria sp. HHY‐2

Published:2024-06-11 Issue:7 Volume:21 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Zhu Li¹,Zhang Sheng‐Qi¹,Wang Yi‐Nong¹,Wang Jia‐Xin¹,Wang Cheng‐Yao¹,Cai Lan¹,Wen Zhao‐Fei¹,Deng Liang²³,Cai Le¹^ORCID

Affiliation:

1. Key laboratory of Medicinal Chemistry for Natural Resource Ministry of Education Yunnan Characteristic Plant Extraction Laboratory Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province School of Chemical Science and Technology Yunnan University Kunming Yunnan 650091 People's Republic of China

2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming Yunnan 650091 People's Republic of China

3. Yunnan College of Modern Biomedical Industry Kunming 650500 People's Republic of China

Abstract

AbstractA new compound xylarkarynone A (1), a first reported natural product compound xylarkarynone B (2) and eight known compounds (3‐10) were isolated from Xylaria sp. HHY‐2. Their structures were elucidated by spectroscopic methods, DP4+ probability analyses and electronic circular dichroism (ECD) calculations. The bioactivities of isolated compounds were assayed. Compound 1 exhibited obvious activity against A549 cells with an IC50 value of 6.12±0.28 μM. Additionally, compound 1 showed moderate antifungal activities against Plectosphaerella cucumerina and Aspergillus niger with minimum inhibitory concentrations (MICs) of both 16 μg/mL, which was at the same grade with positive control nystatin. Most compounds exhibited varying degrees of inhibitory activity against P. cucumerina, indicating that Xylaria sp. has potential as inhibitors against P. cucumerina.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202400900

Reference28 articles.

1. Recent developments and future prospects of antimicrobial metabolites produced by endophytes

2. Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites

3. Endophytic fungi: a source of novel biologically active secondary metabolites

4. Natural products: A continuing source of novel drug leads

5. J. Webster R. Weber Cambridge University Press2007 3 rd Ed 143.