Affiliation:
1. Department of Drugs and Medicines São Paulo State University (Unesp) School of Pharmaceutical Sciences Araraquara-Jaú Road, Km 01, s/n 14.800-903 Araraquara, SP Brazil
2. Center of Pharmacometrics & Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando USA FL 32827
3. Department of Chemistry University of São Paulo (USP) Faculty of Philosophy, Sciences and Letters Av. do Café, s/n 14.040-903 Ribeirão Preto, SP, Brazil
Abstract
AbstractCasearia species are found in the America, Africa, Asia, and Australia and present pharmacological activities, besides their traditional uses. Here, we reviewed the chemical composition, content, pharmacological activities, and toxicity of the essential oils (EOs) from Casearia species. The EO physical parameters and leaf botanical characteristics were also described. The bioactivities of the EOs from the leaves and their components include cytotoxicity, anti‐inflammatory, antiulcer, antimicrobial, antidiabetic, antioxidant, antifungal, and antiviral activities. The main components associated with these activities are the α‐zingiberene, (E)‐caryophyllene, germacrene D, bicyclogermacrene, spathulenol, α‐humulene, β‐acoradiene, and δ‐cadinene. Data on the toxicity of these EOs are scarce in the literature. Casearia sylvestris Sw. is the most studied species, presenting more significant pharmacological potential. The chemical variability of EOs components was also investigated for this species. Caseria EOs have relevant pharmacological potential and must be further investigated and exploited.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering