Discovery of Four New Compounds from Macropanax membranifolius and Their Cytotoxic Activity

Author:

Hang Pham Thi12,Hue Nguyen Thi1,Nam Nguyen Hoang1,Tuan Nguyen Le3,Cuong Pham Van12,Vuong Nguyen Quoc12,Hang Dan Thi Thuy1,Tai Bui Huu12,Kiem Phan Van12ORCID

Affiliation:

1. Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam E-mail: s: (P.V.K.

2. Graduate University of Science and Technology VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam

3. Natural Science department Quy Nhon University 170 An Duong Vuong Quy Nhon, Binh Dinh 590000 Vietnam

Abstract

AbstractA phytochemical investigation of the methanolic extract of the Macropanax membranifolius C.B. Shang leaves led to the isolation of three new flavans, (2R,3R)‐4′‐O‐methylcatechin 5‐O‐β‐D‐glucopyranoside (1), (2S,3S)‐4′‐O‐methylcatechin 5‐O‐β‐D‐glucopyranoside (2), (2S,3R)‐4′‐O‐methylcatechin 5‐O‐β‐D‐glucopyranoside (3), one new triterpene glycoside 3‐O‐β‐D‐xylopyranosyl‐(1→6)‐[β‐D‐xylopyranosyl‐(1→2)]‐β‐D‐glucopyranosyl‐oleanolic acid 28‐O‐β‐D‐glucopyranoside (4), together with nine known compounds (513). Their chemical structures were elucidated based on HR‐ESI‐MS, NMR spectroscopic data. The absolute configurations of compounds 13 were established by electronic circular dichroism (ECD) spectra. At concentration of 20 μM, compounds 113 showed the percentages of dead cell in the range of 2.14 % to 33.61 % against KB, HepG2, HL60, P388, HT29, and MCF7 cancerous cell lines by SRB assay.

Funder

National Foundation for Science and Technology Development

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3