Systematic Chemical Analysis of Crude Glycan Isolates from the Seven‐Herb Decoction Quanzhenyiqitang with Anti‐COPD Activity

Author:

Yu Xiaoxian1,Dai Shiting23,Dai Longchao1,Ao Ran2,Zhang Dapeng2,Wang Lingchong1ORCID

Affiliation:

1. School of Pharmacy Nanjing University of Chinese Medicine 210023 Nanjing City Jiangsu Province P. R. China

2. Department of Traditional Chinese Medicine First Affiliated Hospital of Guangzhou Medical University 510120 Guangzhou City Guangdong Province P. R. China

3. Integrated Traditional Chinese and Western Medicine Guangzhou Medical University 510180 Guangzhou City Guangdong Province P. R. China

Abstract

AbstractThe classical Chinese Medicine prescription, Quanzhenyiqitang (QZYQT), containing seven tonic herbs (Shudi, Dangshen, Maidong, Baizhu, Niuxi, Fuzi, and Wuweizi) is clinically used to treat chronic obstructive pulmonary disease (COPD). Although there are studies on the pharmacological effects of QZYQT, little attention has been paid to its active carbohydrate ingredients. We performed a systematic chemical analysis of the crude glycan isolates from the seven‐herb decoction (GI‐QZYQT) after confirming its anti‐COPD activity. GI‐QZYQT could enhance lung function, reduce lung damage, and alleviate inflammatory response in mice with COPD. Moreover, two monosaccharides (fructose and glucose) and six oligosaccharides (sucrose, melibiose, 1‐kestose, raffinose, mannotriose, and stachyose), accounting for 40.23 % of GI‐QZYQT, were discovered using hydrophilic interaction liquid chromatography–evaporative light‐scattering detection. Inulin‐type fructan with an average molecular weight of 2112 Da was identified using high‐performance gel‐permeation chromatography in combination with monosaccharide mapping analysis, accounting for 20.10 % of GI‐QZYQT in mass. The comparison study showed that the identified monosaccharides, oligosaccharides, and the inulin‐type fructan of GI‐QZYQT were mainly derived from herbs of Shudi, Dangshen, Maidong, Baizhu, and Niuxi. These findings provide crucial information on the chemical composition of GI‐QZYQT, which is vital for the in‐depth understanding of its bioactivity, mechanism, and product development.

Publisher

Wiley

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