Antifungal Activity of Cadinane‐Type Sesquiterpenes from Eupatorium adenophorum against Wood‐Decaying Fungi

Abstract

AbstractThe present study aimed to evaluate the antifungal activities of Eupatorium adenophorum against four strains of wood‐decaying fungi, including Inonotus hispida, Inonotus obliquus, and Inonotus cuticularis. Bioguided isolation of the methanol extract of E. adenophorum by silica gel column chromatography and high‐performance liquid chromatography afforded six cadinane‐type sesquiterpenes. Their structures were identified by nuclear magnetic resonance and MS analyses. According to the antifungal results, the inhibition rate of the compound was between 59.85 % and 77.98 % at a concentration of 200 μg/mL. The EC50 values ranged from 74.5 to 187.4 μg/mL.