Affiliation:
1. Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 China
2. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China
Abstract
AbstractOne new fatty acid derivative, (2E,4E)‐6,7‐dihydroxy‐2‐methylocta‐2,4‐dienoic acid (1), and 16 known compounds (2–17) were isolated from the mangrove sediment derived fungus Trichoderma harzianum SCSIO 41051. Their structures were established by spectroscopic methods, computational ECD, and Mo2(OAc)4‐induced ECD experiment. All the compounds were evaluated for their acetylcholinesterase (AChE) and pancreatic lipase (PL) inhibition. Compounds 9 and 14 exhibited moderate AChE inhibitory activities with IC50 values of 2.49 and 2.92 μM, respectively, which compounds 8 and 9 displayed moderate inhibition on PL with IC50 value of 2.30 and 2.34 μM, respectively.
Funder
Natural Science Foundation of Guangdong Province
Cited by
1 articles.
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