Pelliolatifolias A‐D, Four Undescribed Compounds from Pellionia latifolia Boerl. and Their Nitric Oxide Production Inhibitory Activity

Abstract

AbstractFour undescribed compounds (1–4) named pelliolatifolias A−D together with seven known compounds trans‐clovamide (5), N‐trans‐caffeoyl‐4‐hydroxyphenylalanine methyl ester (6), N‐trans‐caffeoyl‐3,4‐dihydroxyphenylalanine methyl ester (7), luteolin 4’‐O‐β‐D‐glucopyrannoside (8), cis‐syringin (9), trans‐syringin (10), and citroside A (11) have been isolated from the methanol extract of the Pellionia latifolia leaves. Their chemical structures were elucidated based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR, and CD spectra. Compounds 1–7, 9 and 10 showed moderate inhibition of NO production in LPS‐activated RAW264.7 cells with their IC50 values ranging from 39.27 to 75.42 μM, compared to that of the positive control compound, dexamethasone, IC50 value of 14.20 μM.