Chamomile Essential Oil: Chemical Constituents and Antitumor Activity in MDA‐MB‐231 Cells through PI3K/Akt/mTOR Signaling Pathway

Author:

An Zhonghua1,Feng Xuelin1,Sun Mengjia1,Wang Yifan1,Wang Hongbo2,Gong Yanling1ORCID

Affiliation:

1. Department of Pharmacy College of Chemical Engineering Qingdao University of Science and Technology 53 Zhengzhou Road Qingdao 266042 Shandong China

2. Department of Gastrointestinal Surgery Jimo District People's Hospital 38 Jianmin Street, Qingdao Qingdao 266042 Shandong China

Abstract

AbstractChamomile essential oil (CEO) is extracted from chamomile and mainly used in aromatherapy. The chemical constituents and its antitumor activity on Triple‐negative breast cancer (TNBC) was explored in the present study. Gas chromatography‐mass spectrometry (GC/MS) was employed to analyze the chemical constituents of CEO. The cell viability, migration and invasion of TNBC cell MDA‐MB‐231 were measured using MTT, wound scratch and Transwell assay, respectively. The protein expression of PI3K/Akt/mTOR signaling pathway was determined by Western blot. CEO is rich in terpenoids (63.51 %), among which the identified terpenoids and their derivatives are mainly Caryophyllene (29.57 %), d‐Cadinene (12.81 %), Caryophyllene oxide (14.51 %), etc. Three concentration of CEO (1, 1.5, 2 μg/mL) significantly inhibited the proliferation, migration and invasion of MDA‐MB‐231 cells with a dose dependent manner. Moreover, the phosphorylation of PI3K, Akt and mTOR was inhibited by CEO. The results revealed that there was abundant terpenoids in the CEO which account for 63.51 %. CEO significantly inhibited the proliferation, migration and invasion of MDA‐MB‐231 cells, exhibiting antitumor effect on TNBC. The antitumor effect of CEO might attribute to its inhibition on PI3K/Akt/mTOR signaling pathway. However, further study should be conducted in more TNBC cell lines and animal models to provide further evidence for TNBC treatment by CEO.

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

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