Phytochemical Research and Anti‐Inflammatory Activities of the Ethanol Extract from Anoectochilus Roxburghii (Wall.) Lindl

Author:

Yao Guang‐Xiao1,Zhang Jian23,Wu Mei4,Yao Zhi‐Ren1,Huang Ya‐Ping1,Mu Long1,Wang Lei1,Pan Ke1,Yin Zhi‐Qi1ORCID,Song Zhe1

Affiliation:

1. School of Traditional Chinese Pharmacy & China Pharmaceutical University Center for Analysis and Testing China Pharmaceutical University Nanjing 211198 China

2. Nanjing Lishui District Hospital of Traditional Chinese Medicine Nanjing 211200 China

3. Afiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing 210028 China

4. Jinhua Academy of Agricultural Sciences Jinhua 321017 China

Abstract

AbstractAnoectochilus roxburghii is a well‐known and valuable traditional Chinese herb due to various medicinal and functional benefits. In‐depth investigation is necessary to discover active ingredients and expand its application. In this study, four new compounds (14) along with ten known compounds (514) were isolated from the ethanol extract of A.roxburghii. Their structures were elucidated by spectroscopic data interpretation. The isolates were screened for their inhibitory activities on the production of NO in lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophages. Among them, compounds 5, 6, 9, 10, 12, 13 and 14 exhibited significant anti‐inflammatory activity through inhibiting the release of NO.

Publisher

Wiley

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