Design, Synthesis, and Insecticidal Activities of Novel N‐Pyridylpyrazole Amide Derivatives Containing a Maleimide

Author:

Zhang Lu1,Kong Yijin1,Shao Xusheng12ORCID,Li Zhong12ORCID

Affiliation:

1. Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China

2. State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 China

Abstract

AbstractTo discover ‘me‐better’ insecticidal active molecules targeting ryanodine receptors (RyRs), a series of novel N‐pyridylpyrazole amide derivatives containing a maleimide were designed and synthesized in accordance with the prior investigations of our group. Preliminary bioassay findings indicated some compounds containing a maleimide exhibited good larvicidal activities against lepidopteran pests at a concentration of 500 mg L−1. Compound 9 j showed 60 % larvicidal activities against M. Separata at 50 mg L−1. Compound 9 b exhibited 40 % larvicidal activities against P. xylostella at 50 mg L−1. Molecular docking study indicated that H‐bonds, π–π interaction and cation‐π interaction made for the binding of compounds 9 b, 9 j with P. Xylostella RyR. These results indicated that compounds 9 b and 9 j could be developed as novel and promising insecticidal leads.

Funder

Shanghai Municipal Education Commission

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

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