Affiliation:
1. College of Pharmacy Shenzhen Technology University Shenzhen 518118 People's Republic of China
2. Science and Technology Innovation Center Guangzhou University of Chinese Medicine Guangzhou 510405 People's Republic of China
3. State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University Guangzhou 510632 People's Republic of China
Abstract
AbstractFour new prenylated acetophenone derivatives, including one acetophenone dimer [acronyrone D (1)] and three acetophenone monomers [acronyrones E−G (2–4)], along with seven known analogues (5–11) were obtained from the leaves of Acronychia pedunculata. Their structures and absolute configurations were established by analysis of HRMS and NMR data, single crystal X‐ray diffraction studies and quantum chemical calculations. In addition, the isolates were tested for their anti‐proliferative acivity against HCT‐116, RKO and SW480 cancer cell lines. Compound 5 exhibited significant anti‐proliferative effects on the three cell lines, with IC50 values ranging from 0.24–5.3 μM.
Funder
National Natural Science Foundation of China