Antifungal Activity, Antibiofilm and Association Studies with <i>O</i>‐Alkylamidoximes against <i>Cryptococcus</i> spp.-Reference-Cited by-同舟云学术

Antifungal Activity, Antibiofilm and Association Studies with O‐Alkylamidoximes against Cryptococcus spp.

Published:2023-02-15 Issue:3 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

de Castro Teixeira Anna Paula¹^ORCID,Fernandes Queiroga Moraes Gustavo²^ORCID,de Oliveira Romário Jonas³^ORCID,Silva Santos Cosme³^ORCID,Alves Caiana Rodrigo Ribeiro¹^ORCID,Rufino de Freitas Juliano Carlo¹³^ORCID,Vasconcelos Ulrich⁴^ORCID,de Oliveira Pereira Fillipe²^ORCID,Oliveira Lima Igara¹^ORCID

Affiliation:

1. Postgraduate Program in Natural Sciences and Biotechnology Education and Health Center Federal University of Campina Grande Cuité Brazil

2. Biochemistry Laboratory Education and Health Center Federal University of Campina Grande Cuité Brazil

3. Postgraduate Program in Chemistry Federal Rural University of Pernambuco Recife Brazil

4. Laboratory of Animal Microbiology Biotechnology Center Federal University of Paraíba João Pessoa Brazil

Abstract

AbstractThis is the first study that describes the antifungal and anti‐biofilm potential of O‐alkylamidoximes against strains of Cryptococcus neoformans and Cryptococcus gattii. In vitro tests have shown that O‐alkylamidoximes are capable of inhibiting fungal growth and biofilm formation of the C. neoformans and C. gattii strains, suggesting, from molecular docking, the potential for interaction with the Hsp90. The associations between O‐alkylamidoximes and amphotericin B were beneficial. Therefore, O‐alkylamidoximes can be a useful alternative to contribute to the limited arsenal of drugs, since they showed a powerful action against the primary agents of Cryptococcosis.

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202200539

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