Affiliation:
1. Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical Sciences, Health Science Center Shenzhen University Shenzhen 518060 P. R. China
2. State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine Chengdu 611137 P. R. China
3. Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products School of Life Sciences and Food Engineering Hanshan Normal University Chaozhou 521041 P. R. China
Abstract
AbstractZizhines V, W, Y, Z, (±)‐zizhines X, and Z1−Z3, and (±)‐ganosinensol L, thirteen new compounds including four pairs of enantiomers and a known compound (−)‐ganosinensol L, were isolated from the fruiting bodies of Ganoderma sinensis. Their structures were identified by spectroscopic, computational methods, and CD (circular dichroism spectroscopy) comparisons. Zizhines V−Z and Z1−Z3 are meroterpenoids consisting of the phenolic and the terpenoidal parts. All the compounds except zizhine Z3 bear a common trans‐p‐hydroxycinnamoyl group. Biological evaluation shows that (−)‐zizhine Z1 inhibits cell migration in the MDA‐MB‐231 cell lines. The present study discloses the chemical profiling of G. sinensis and paves the way for its development as functional products to benefit chronic disorders.
Funder
National Natural Science Foundation of China
National Science Fund for Distinguished Young Scholars
Shenzhen University
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
1 articles.
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