Affiliation:
1. Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima University Hiroshima Japan
2. Division of Abdominal Transplant Stanford University School of Medicine Stanford California USA
3. Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research Hiroshima University Hospital Hiroshima Japan
Abstract
AbstractThis review discusses the increasing global trend towards an aging population, which has resulted in a growing number of surgeries being performed on elderly patients, particularly those living with cancer. The focus was on the implications of abdominal aortic calcification (AAC), an indicator of systemic atherosclerosis, in these patients. This comprehensive review provided evidence detailing the complex processes of atherosclerosis and vascular calcification and various approaches to assess this condition. The prevalence of AAC is related to multiple factors, including cardiovascular disease, inflammation, frailty in various types of gastroenterological surgery. Additionally, notable links were found between AAC, postoperative complications, and patient survival following gastroenterological surgery. This study highlights how AAC could negatively impact the health status of elderly patients and undermine treatment efficacy, stressing the need for more research in this domain to improve patient outcomes.
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development