Peritoneal lavage cytology in patients with curative resection for stage <scp>II</scp> and <scp>III</scp> colorectal cancer: A multi‐institutional prospective study-Reference-Cited by-同舟云学术

Peritoneal lavage cytology in patients with curative resection for stage II and III colorectal cancer: A multi‐institutional prospective study

Published:2024-05-27 Issue:5 Volume:8 Page:807-816
ISSN:2475-0328
Container-title:Annals of Gastroenterological Surgery
language:en
Short-container-title:Annals of Gastroent Surgery

Author:

Kobayashi Hirotoshi¹²^ORCID,Kotake Kenjiro³,Maeda Kotaro⁴,Suto Takeshi⁵,Kawasaki Masayasu⁶^ORCID,Ueno Hideki⁷^ORCID,Komori Koji⁸^ORCID,Ozawa Heita⁹,Koda Keiji¹⁰,Ohue Masayuki¹¹,Funahashi Kimihiko¹²,Takemasa Ichiro¹³^ORCID,Ishida Hideyuki¹⁴,Kazama Shinsuke¹⁵,Shimada Yoshifumi¹⁶^ORCID,Morohashi Hajime¹⁷^ORCID,Kinugasa Yusuke¹⁸^ORCID,Kanemitsu Yukihide¹⁹,Ochiai Hiroki²⁰,Ishihara Soichiro²¹,Itabashi Michio²²,Sugihara Kenichi²³,Ajioka Yoichi²⁴

Affiliation:

1. Department of Surgery Tokyo Metropolitan Hiroo Hospital Tokyo Japan

2. Department of Surgery Teikyo University Hospital Mizonokuchi Kanagawa Japan

3. Department of Surgery Sano City Hospital Tochigi Japan

4. International Medical Center Fujita Health University Hospital Toyoake Japan

5. Department of Gastroenterological Surgery Yamagata Prefectural Central Hospital Yamagata Japan

6. Department of Surgery Bell Land General Hospital Sakai Japan

7. Department of Surgery National Defense Medical College Tokorozawa Japan

8. Department of Gastroenterological Surgery Aichi Cancer Center Hospital Aichi Japan

9. Department of Surgery Tochigi Cancer Center Utsunomiya Japan

10. Teikyo University Chiba Medical Center Ichihara City Japan

11. Department of Gastroenterological Surgery Osaka International Cancer Institute Osaka Japan

12. Department of General and Gastroenterological Surgery Toho University Omori Medical Center Tokyo Japan

13. Department of Surgery, Surgical Oncology and Science Sapporo Medical University Sapporo Japan

14. Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University Kawagoe Japan

15. Department of Gastroenterological Surgery Saitama Cancer Center

16. Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan

17. Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Aomori Japan

18. Department of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo Japan

19. Department of Colorectal Surgery National Cancer Center Hospital Tokyo Japan

20. Department of Surgery Teikyo University School of Medicine Tokyo Japan

21. Department of Surgical Oncology The University of Tokyo Hospital Tokyo Japan

22. Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan

23. Tokyo Medical and Dental University Tokyo Japan

24. Division of Molecular and Diagnostic Pathology Niigata University, Graduate School of Medical and Dental Sciences Niigata Japan

Abstract

AbstractAimTo clarify the usefulness of intraoperative lavage cytology in patients undergoing curative resection for pStage II‐III colorectal cancer in a prospective multicenter study.MethodsPatients preoperatively diagnosed with stage II‐III colorectal cancer between 2013 and 2017 from 20 hospitals were enrolled. Lavage cytology was performed twice during the surgery. The primary endpoint was the effect of lavage cytology on the 5‐year relapse‐free survival (RFS) in patients with pStage II‐III colorectal cancer. The secondary endpoint was the effect of lavage cytology on the 5‐year overall survival (OS) and peritoneal recurrence.ResultsA total of 1378 patients were eligible for analysis. The number of patients with pStage II‐III colorectal cancer was 670 and 708, respectively. Fifty‐four patients (3.9%) had positive cytological results. In pStage II patients, the 5‐year RFS rates with positive and negative cytology were 61.1% and 81.6%, respectively (p = 0.023). The 5‐year OS rates were 67.1% and 91.7%, respectively (p = 0.0083). However, there was no difference in RFS or OS between pStage III patients with positive and negative cytology results. The peritoneal recurrence rates were 11.8% and 1.5% in pStage II patients with positive and negative cytology results, respectively (p = 0.032). These rates were 10.5% and 2.5% in patients with stage III disease, respectively (p = 0.022).ConclusionStage II colorectal cancer patients with negative cytology had better outcomes than those with positive cytology. Peritoneal lavage cytology is useful for predicting peritoneal recurrence after curative resection of stage II‐III colorectal cancer.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ags3.12825

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