Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Author:

Thijssen Victor LJL12,Paulis Yvette WJ13,Nowak-Sliwinska Patrycja14,Deumelandt Katrin L1,Hosaka Kayoko5,Soetekouw Patricia MMB3,Cimpean Anca M6,Raica Marius6,Pauwels Patrick7,van den Oord Joost J8,Tjan-Heijnen Vivianne CG3,Hendrix Mary J9,Heldin Carl-Henrik10,Cao Yihai5,Griffioen Arjan W1ORCID

Affiliation:

1. Angiogenesis Laboratory, Department of Medical Oncology; VU University Medical Center; Amsterdam The Netherlands

2. Department of Radiation Oncology; VU University Medical Center; Amsterdam The Netherlands

3. Division of Medical Oncology, GROW - School for Oncology and Developmental Biology; Maastricht University Medical Center; Maastricht The Netherlands

4. School of Pharmaceutical Sciences; University of Geneva; Geneva Switzerland

5. Department of Microbiology, Tumor and Cell Biology; Karolinska Institute; Stockholm Sweden

6. Department of Microscopic Morphology, Histology, Angiogenesis Research Center; Victor Babes University of Medicine and Pharmacy; Timisoara Romania

7. Department of Pathology; Antwerp University Hospital; Edegem Belgium

8. Laboratory of Translational Cell and Tissue Research; University of Leuven; Leuven Belgium

9. Department of Biology, Shepherd University; Shepherdstown University; WV USA

10. Department of Medical Biochemistry and Microbiology, Science for Life Laboratory; Uppsala University; Uppsala Sweden

Funder

KWF Kankerbestrijding

Profileringsfonds AZM

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference63 articles.

1. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma;Hendrix;Nat Rev Cancer,2003

2. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry;Maniotis;Am J Pathol,1999

3. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells;Ricci-Vitiani;Nature,2010

4. Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry;Ruf;Cancer Res,2003

5. Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia;Schaft;Cancer Res,2005

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