Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses
Author:
Affiliation:
1. Proteon Therapeutics Waltham Massachusetts
2. Biopta, Ltd. Glasgow United Kingdom
3. The University of Texas Health Science Center Tyler Texas
Funder
Proteon Therapeutics, Inc.
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,Neurology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.229
Reference18 articles.
1. In Vivo Vascular Engineering of Vein Grafts: Directed Migration of Smooth Muscle Cells by Perivascular Release of Elastase Limits Neointimal Proliferation
2. Local application of recombinant human type I pancreatic elastase (PRT‐201) to an arteriovenous fistula (AVF) increases AVF blood flow in a rabbit model;Burke SK;J Am Soc Nephrol,2008
3. Time‐ and concentration‐dependent effects of recombinant human elastase (PRT‐201) on the elastin content of human upper extremity veins treated ex vivo;Burke SK;J Am Soc Nephrol,2009
4. Elastase Promotes Aortic Dilation by Inhibiting Ca2+ Influx into Vascular Smooth Muscle
5. Elastolytic and Collagenolytic Studies of Arteries
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