Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells

Author:

Tai Mi-Hsueh1,Chen Po-Kong1,Chen Pei-Yi2,Wu Ming-Jiuan3,Ho Chi-Tang4,Yen Jui-Hung1

Affiliation:

1. Department of Molecular Biology and Human Genetics; Tzu Chi University; Hualien Taiwan

2. Center of Medical Genetics; Buddhist Tzu Chi General Hospital; Hualien Taiwan

3. Department of Biotechnology; Chia Nan University of Pharmacy and Science; Tainan Taiwan

4. Department of Food Science; Rutgers University; NJ USA

Funder

Ministry of Science and Technology, Taiwan

Publisher

Wiley

Subject

Food Science,Biotechnology

Reference68 articles.

1. Mortality and coronary heart disease among men studied for 23 years;Keys;Arch. Intern. Med.,1971

2. The LDL receptor: how acid pulls the trigger;Beglova;Trends Biochem. Sci.,2005

3. The LDL receptor;Goldstein;Arterioscler. Thromb. Vasc. Biol.,2009

4. Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia;Innerarity;J. Lipid Res.,1990

5. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia;Abifadel;Nat. Genet.,2003

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