Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract

Author:

Atwell Lauren L.1,Hsu Anna1,Wong Carmen P.1,Stevens Jan F.23,Bella Deborah1,Yu Tian-Wei2,Pereira Clifford B.4,Löhr Christiane V.5,Christensen John Mark3,Dashwood Roderick H.6,Williams David E.27,Shannon Jackilen8,Ho Emily129

Affiliation:

1. School of Biological and Population Health Sciences; Oregon State University; Corvallis OR USA

2. Linus Pauling Institute; Oregon State University; Corvallis OR USA

3. Department of Pharmaceutical Sciences; Oregon State University; Corvallis OR USA

4. Department of Statistics; Oregon State University; Corvallis OR USA

5. College of Veterinary Medicine; Oregon State University; Corvallis OR USA

6. Center for Epigenetics and Disease Prevention; Texas A&M Health Science Center; Houston TX USA

7. Department of Environmental and Molecular Toxicology; Oregon State University; Corvallis OR USA

8. Department of Public Health and Preventive Medicine; Oregon Health and Science University; Portland OR USA

9. Moore Family Center for Whole Grain Foods; Nutrition and Preventive Health; Oregon State University; Corvallis OR USA

Funder

National Institute of Health - National Cancer Institute

Publisher

Wiley

Subject

Food Science,Biotechnology

Reference37 articles.

1. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane;Brooks;Cancer Epidemiol. Biomarkers Prev.,2001

2. Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo;Petri;Drug Metab. Dispos.,2003

3. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds;Munday;J. Agric. Food Chem.,2004

4. A novel mechanism of chemoprotection by sulforaphane;Myzak;Cancer Res.,2004

5. Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects;Myzak;Exp. Biol. Med.,2007

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