Affiliation:
1. School of Ophthalmology & Optometry and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang China
2. Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine Vision and Brain Health Zhejiang China
3. Institute of PSI Genomics Zhejiang China
Abstract
AbstractThe prevalence of ocular disorders is dramatically increasing worldwide, especially those that cause visual impairment and permanent loss of vision, including cataract, glaucoma, age‐related macular degeneration, and diabetic retinopathy. Extensive evidence has shown that ncRNAs are key regulators in various biogenesis and biological functions, controlling gene expression related to histogenesis and cell differentiation in ocular tissues. Aberrant expression and function of ncRNA can lead to dysfunction of visual system and mediate progression of eye disorders. Here, we mainly offer an overview of the role of precise modulation of ncRNAs in eye development and function in patients with eye diseases. We also highlight the challenges and future perspectives in conducting ncRNA studies, focusing specifically on the role of ncRNAs that may hold expanded promise for their diagnostic and therapeutic applications in various eye diseases.This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
RNA in Disease and Development > RNA in Disease
RNA in Disease and Development > RNA in Development
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Subject
Molecular Biology,Biochemistry
Cited by
1 articles.
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