Avoiding Tacrolimus Underexposure and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial

Author:

Francke Marith I.123,Andrews Louise M.45,Le Hoang Lan4,Wetering Jacqueline12,Clahsen‐van Groningen Marian C.26,Gelder Teun7,Schaik Ron H. N.8,Holt Bronno9,Winter Brenda C. M.24,Hesselink Dennis A.12

Affiliation:

1. Department of Internal Medicine Division of Nephrology and Transplantation Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands

2. Rotterdam Transplant Group Rotterdam The Netherlands

3. Netherlands Institute for Health Sciences Rotterdam The Netherlands

4. Department of Hospital Pharmacy Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands

5. Department of Hospital Pharmacy Meander Medical Center Amersfoort The Netherlands

6. Department of Pathology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands

7. Department of Clinical Pharmacy and Toxicology Leiden University Medical Center Leiden The Netherlands

8. Department of Clinical Chemistry Erasmus MC University Medical Center Rotterdam The Netherlands

9. Department of Hematology Erasmus MC Cancer Institute Rotterdam The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference48 articles.

1. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report

2. Prograf Summary of product characteristics (European Medicines Agency(2006) .

3. KDIGO clinical practice guideline for the care of kidney transplant recipients;Kidney Disease: Improving Global Outcomes Transplant Working Group;Am. J. Transplant.,2009

4. Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Starting Dose

5. Explaining Variability in Tacrolimus Pharmacokinetics to Optimize Early Exposure in Adult Kidney Transplant Recipients

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