Effect of N -methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide-Reference-Cited by-同舟云学术

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Effect of N -methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide

Published:2017-05-30 Issue:9 Volume:60 Page:401-409
ISSN:0362-4803
Container-title:Journal of Labelled Compounds and Radiopharmaceuticals
language:en
Short-container-title:J. Label Compd. Radiopharm

Author:

Pang Xuehai¹²^ORCID,Peng Lingling³,Chen Yuanwei¹²³⁴

Affiliation:

1. Chengdu Institute of Organic Chemistry; University of Chinese Academy of Sciences; Chengdu China

2. University of Chinese Academy of Sciences; Beijing China

3. Lab of YWChen, Cancer Center, West China Hospital; Sichuan University and Collaborative Innovation Center; Chengdu China

4. Hinova Pharmaceuticals Inc; Chengdu China

Funder

National Natural Science Foundation of China

Hinova Pharmaceuticals Inc

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference34 articles.

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3. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model;Handratta;J Med Chem,2005

4. Discovery and development of galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer;Njar;J Med Chem,2015

5. Role of maximal androgen blockade in advanced prostate cancer;Denis;Prostate Canc,1994

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3. Cobalt-catalyzed dehalogenative deuterations with D2O;Chinese Journal of Catalysis;2024-04

4. Trideuteromethylation of Alkyl and Aryl Bromides by Nickel-Catalyzed Electrochemical Reductive Cross-Electrophile Coupling;Synlett;2024-03-04

5. Effect of position of deuterium atoms on gas chromatographic isotope effects;Talanta;2023-12

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