Pharmacometric Modeling of Naloxegol Efficacy and Safety: Impact on Dose and Label

Author:

Al-Huniti N1,Zhou D1,Xu H1,Aksenov S1,Bui KH1,Fox R1,Helmlinger G1,Stanski D1

Affiliation:

1. Quantitative Clinical Pharmacology; AstraZeneca LP; Waltham Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference10 articles.

1. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden.;Panchal;Int. J. Clin. Pract.,2007

2. Novel opioid antagonists for opioid-induced bowel dysfunction.;Diego;Expert. Opin. Investig. Drugs,2011

3. A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation.;Webster;Pain,2013

4. Movantik™ (naloxegol) Full Prescribing Information. AstraZeneca Pharmaceuticals LP, Wilmington, DE 2014

5. Moventig® (naloxegol) Full Prescribing Information. AstraZeneca AB, Södertälje, Sweden 2014

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